Study of genes involved in angiogenesis and metabolic processes of peripheral blood lymphocytes in patients with chronic endometritis

Objective. To study the polymorphisms of genes involved in angiogenesis and metabolic processes, to assess level lymphocytes patients with chronic endometritis practically healthy women reproductive period.
 Materials methods. 86 were examined; DNA regions eNOS 1799983 (Glu298Asp), PPARA (G2528C), ApoE rs429358 (Cys130Arg), MTHFR (C677T, A1298C) used as primers; blood (CD3+, CD4+, CD8+, CD19+, CD95+) assessed.
 Results. Statistically significant differences gynecological somatic pathology obtained endometritis; they more often than had rs429358, eNOS1799983, (G2528C); dysregulation immune system form insufficiency cellular effector link immunity changes PPARA, ApoE, gene. Attention was drawn relationships polymorphic clinical manifestations endometritis, particular, a history non-developing pregnancy anamnesis, there detected polymorphism gene, abnormal uterine bleeding inflammatory gallbladder gene.
 Conclusions. The prevalence endometrial inflammation compared participants study. Insufficiency revealed majority ChE an association allele C genotypes G/C C/C 4253778 ApoE42935 gene genotype A1298C).